Modified-release dosage is a mechanism that (in contrast to immediate-release dosage) delivers a drug with a delay after its administration (delayed-release dosage) or for a prolonged period of time (extended-release [ER, XR, XL] dosage) or to a specific target in the body (targeted-release dosage).Sustained-release dosage forms are dosage forms designed to release (liberate) a drug at a predetermined rate in order to maintain a constant drug concentration for a specific period of time with minimum side effects. This can be achieved through a variety of formulations, including liposomes and drug-polymer conjugates (an example being hydrogels). Sustained release's definition is more akin to a "controlled release" rather than "sustained".
Extended-release dosage consists of either sustained-release (SR) or controlled-release (CR) dosage. SR maintains drug release over a sustained period but not at a constant rate. CR maintains drug release over a sustained period at a nearly constant rate.Sometimes these and other terms are treated as synonyms, but the United States Food and Drug Administration has in fact defined most of these as different concepts. Sometimes the term "depot tablet" is used by non-native speakers, but this is not found in any English dictionaries and is a literal translation of the term used in Swedish and some other languages.
Modified-release dosage and its variants are mechanisms used in tablets (*****) and capsules to dissolve a drug over time in order to be released slower and steadier into the bloodstream while having the advantage of being taken at less frequent intervals than immediate-release (IR) formulations of the same drug. For example, extended-release morphine enables people with chronic pain to only take one or two tablets per day.
Most commonly it refers to time-dependent release in oral dose formulations. Timed release has several distinct variants such as sustained release where prolonged release is intended, pulse release, delayed release (e.g. to target different regions of the GI tract) etc. A distinction of controlled release is that it not only prolongs action, but it attempts to maintain drug levels within the therapeutic window to avoid potentially hazardous peaks in drug concentration following ingestion or injection and to maximize therapeutic efficiency.
In addition to *****, the mechanism can also apply to capsules and injectable drug carriers (that often have an additional release function), forms of controlled release medicines include gels, implants and devices (e.g. the vaginal ring and contraceptive implant) and transdermal patches.
Examples for cosmetic, personal care, and food science applications often centre on odour or flavour release.
The release technology scientific and industrial community is represented by the Controlled Release Society (CRS). The CRS is the worldwide society for delivery science and technologies. CRS serves more than 1,600 members from more than 50 countries. Two-thirds of CRS membership is represented by industry and one-third represents academia and government. CRS is affiliated with the Journal of Controlled Release and Drug Delivery and Translational Research scientific journals.
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Announcing Windows 11 Insider Preview Build 22635.3495 (Beta Channel)
Written By
Amanda Langowski
Brandon LeBlanc
published
April 12, 2024
Hello Windows Insiders, today we are releasing Windows 11 Insider Preview Build 22635.3495 (KB5037000) to the Beta Channel.
REMINDER: All Windows Insiders...
!! Para lang tos sa mga may pera na kayang mawala if ever, Risk po Ito katulad ng iba jan pero pag new pa is legit pa!! Wag gamitin ang perang nakalaan okayy? WAG NATIN E SUGAL ANG PERANG IMPORTANTE SALAMAT!
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Announcing Windows 11 Insider Preview Build 22635.3350 (Beta Channel)
Written By
Amanda Langowski
Brandon LeBlanc
publishedMarch 13, 2024
Hello Windows Insiders, today we are releasing Windows 11 Insider Preview Build 22635.3350 (KB5035955) to the Beta Channel.
REMINDER: All Windows Insiders...
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Announcing Windows 11 Insider Preview Build 22635.3276 (Beta Channel)
Written By
Amanda Langowski
Brandon LeBlanc
publishedMarch 4, 2024
Hello Windows Insiders, today we are releasing Windows 11 Insider Preview Build 22635.3276 (KB5034857) to the Beta Channel.
REMINDER: All Windows Insiders...
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Windows 11 build 22635.3140 arrives with Copilot and Start menu changes in Beta Channel
Another preview of Windows 11 arrives in the Beta Channel with minor changes for Copilot and Start menu.
Mauro Huculak@Pureinfotech
February 9, 2024
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Microsoft has now relocated the...
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Hello Windows Insiders, today we are releasing Windows 11 Insider Preview Build 22635.3061 (KB5034215) to the Beta Channel.
REMINDER: All Windows Insiders in the Beta Channel will now be on the same build (Build 22635.xxxx) via an enablement package. For Windows Insiders in the Beta Channel who...
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Hello Windows Insiders, today we are releasing Windows 11 Insider Preview Build 22635.2921 (KB5034212) to the Beta Channel.
REMINDER: All Windows Insiders in the Beta Channel will now be on the same build (Build 22635.xxxx) via an enablement package. For Windows Insiders in the Beta Channel who...
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Release calendar for the month of January 2024 , more titles will be added in the future once announced.
Thanks to edzqwe for helping with the list
Windows 11 present us a creative space where we can pursue our passions through a fresh experience. From a rejuvenated Start menu to new ways to connect to your favourite people, news, games, and content. Windows 11 (ISO Version offline Installer or direct upgrade from Windows Upgrade Features)...
Windows 11 build 22635.2841 (KB5032286) starts removal of Steps Recorder
Steven Parker @aSteveParker · Dec 4, 2023 18:02 EST0
Microsoft has released its latest Windows 11 preview build for members of the Windows Insider Program in the Beta Channel. The build number for this update is...
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