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The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as leak channels which possess Goldman-Hodgkin-Katz (open) rectification. These channels are regulated by several mechanisms including signaling lipids, oxygen tension, pH, mechanical stretch, and G-proteins . Their name is derived from the fact that the α subunits consist of four transmembrane segments, and each pair of transmembrane segments contains a pore loop between the two transmembrane segments. Thus, each subunit has two pore loops. As such, they structurally correspond to two inward-rectifier α subunits and thus form dimers in the membrane (whereas inward-rectifier α subunits form tetramers).
Each single channel does not have two pores; the name of the channel comes from the fact that each subunit has two P (pore) domains in its primary sequence. To quote Rang and Dale (2015), "The nomenclature is
misleading, especially when they are incorrectly referred to as two-pore channels".Below is a list of the 15 known two-pore-domain human potassium channels:

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  1. R

    2 Minutes

    The two minute rule simply states that if you are confronted with a task that takes only two minutes to finish, then do it right now and get it over with! Don’t leave it hanging because pretty soon, you’ll have a collection of 2-minute tasks that would take an hour to complete. Just finished...
  2. R

    Help Guys about bigbigcash task bypass , sa maga master jan sa gameguardian help me.

    So ayun nanga ulit. Gusto ko sanang ma bypass first task ni bigbigcash. Like yung 6ads nya gawin nalang 1ads at yung 4mins gawin nalang 0sec.. Possible to alam ko. Sana may makatulong sa master sa gameguardian.
  3. S

    Closed Is there a specific shape to draw for the task reward?

    Anong shape ba dapat idrawing para makuha yung skin?
  4. X

    Closed Plss help po how to remove google account myphone my87 dtv

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  5. H

    Closed For longer battery life kill app/task :)

    Para hindi mabilis malowbat cp nyo eto install nyo lang at sundin ang mga settings. Tested ko na to, aabot ng 1 day and a half yung batt kasama na wifi at data. Kaya try nyo nalang sa inyo. How to go to settings Open app > menu > settings > set auto kill level to crazy Auto kill Frequency...
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