Elagolix, sold under the brand name Orilissa, is a gonadotropin-releasing hormone antagonist (GnRH antagonist) medication which is used in the treatment of pain associated with endometriosis in women. It is also under development for the treatment of uterine fibroids and heavy menstrual bleeding in women. The medication was under investigation for the treatment of prostate cancer and enlarged prostate in men as well, but development for these conditions was discontinued. Elagolix is taken by mouth once or twice per day. It can be taken for up to 6 to 24 months, depending on the dosage.Side effects of elagolix include menopausal-like symptoms such as hot flashes, night sweats, insomnia, amenorrhea, mood changes, anxiety, and decreased bone density, among others. Elagolix is a GnRH antagonist, or an antagonist of the gonadotropin-releasing hormone receptor (GnRHR), the biological target of the hypothalamic hormone gonadotropin-releasing hormone (GnRH). By blocking the GnRHR, it dose-dependently suppresses the gonadal production and hence circulating levels of *** hormones such as estradiol, progesterone, and testosterone. Elagolix is a short-acting GnRH antagonist, and can be used to achieve either partial or more substantial suppression of *** hormone levels. Reduced estrogen levels in the endometrium are responsible for the efficacy of elagolix in the treatment of endometriosis.Elagolix was first described in 2008 and was approved for medical use in July 2018. It has been described as a "second-generation" GnRH modulator due to its non-peptide and small-molecule nature and its oral activity. Unlike GnRH agonists and older GnRH antagonists, which are peptides and first-generation GnRH modulators, elagolix is not a GnRH analogue as it is not structurally related to GnRH. Elagolix was the first second-generation and orally active GnRH modulator to be introduced for medical use. The introduction of elagolix in the United States and Canada was followed by that of relugolix (brand name Relumina), the next second-generation GnRH antagonist, in Japan in January 2019. The U.S. Food and Drug Administration (FDA) considers it to be a first-in-class medication.
pwede ba na mag apply ng brand new na clearance at hindi " renewal" yung ggawin? ngpapatulong kasi insan ko thanks
alin po dapat pipilin dun ba dapat sa first time job seekers or dun sa renewal lang? di na kasi mahanp yung old na nbi clearance nya eh
May tanong lang po..
Yung sa profile ko po sa NBI yung Place of Birth po ng parent ko po don is kulang ng isang letter.
And ayaw na ma edit.
Ano po kaya pwede gawin?
Pwede po ba mag register ulit?
Okay lang po kaya yun?
Sana po may maka help.
Hello ka-phc, magtatanong Lang para sa first time job seeker, FYI meron na po akong barangay clearance para sa first time job seeker and etc. Bali ang tanong ko lang pwede bang kumuha ng NBI ang currently 17 year's old bale sa October pa this year ako mag-18, bawal pa kaya at kailangan ko pang...
kumuha ako ng nbi clearance tapos may hit, sabi balik daw ako ng may 5
ang iniisip kong dahilan baka sa pag cancel ng appointment, naka 2 or 3 ata akong cancel, saka kase lagi ako naka vpn eh gamit ko now gtm no load.
sa tingin nyo mga paps ano reason?
first time ko lang kukuha nbi gamit first...
First time jobseeker po ako, ang tanong ko lang pag kukuha ba online may pinapapasa na ba na documents? o saka lang ipresent pag sa NBI branch na. Thanks sa sasagot
Nagfile po ako ng nbi appointment as 1st time jobseeker and nakakuha ng reference number kaso di po ako nakapunta ng feb 8,2023.
Ngayon nagtry ako mag pa appointment kaso naavail ko na daw po(see pic) kaya hindi na makakuha ng bagong reference and appointment.
Pwede po kaya pumunta na lng bigla...
Mga lods tanong ko lang po nag pa book ako ng appointment sa NBI malapit samin tas nagpunta na ko kanina sira daw yung machine hindi po naiprocess valid until March 4 pa naman yung appointment ko
Pwede po ba sa ibang location na branch ako kumuha? kung sakaling hindi pa ayos yung malapit sakin?
Mga idol ano ba mga kailangan ko para makakuha ng NBI clearance pag first time job seeker?
Meron na po ako ng
*First-time job seeker certificate
*2valid id
*Barangay Clearance
Ano pa po kaya kailangan ko
Nalilito kasi ako sa nagoogle ko eg hahaha
Salamat
Good day po mag ask sana ako. Regarding sa nbi clearance ko na d ko na claim by the time of appointment due to some urgent work. Now nagkaroon ako ng pending case sa old company ko makukuha ko po ba yun di ko nakuha na cleared and record or may nakalagay na pending case? Need lng sa work salamat...
May nakatry na ba mag refund ng ρáíd NBI clearance reference number?
Nagrequest kasi ako ng clearance, payment via GCash, tapos di ko na naasikaso puntahan sa office, decided to not get it in the end.
Thanks.
Yong 130 sana na babayaran para sa Clearance ay nagiging 235 (sa Region 2, based on experience) para sa mga walk-in applicants (yong mga hindi na nagpa-appointment kasi kung magpa-appointment pa sa website nila, aabutin pa ng isang buwan bago ang schedule)
Ganito yong scheme nila: Kapag...
Good day po. Around 2016 po nahuli ako/kami ng mga kaibigan ko na nagSHOPLIFT sa SM. Minor pa po ako nung time na yun, 16 years old. Dinala kami sa office ng SM tapos kinuha infos namin, names and addresses. Hindi naman po pinabayaran samin, dinala lang kami sa baranggay then pinatubos sa...
Paano po pag di mo nakuha nbi clearance mo lagpas na ng dalawang buwan?
makukuha mo parin ba yun may naka experience na ba sa inyo na sobrang delay na kinuha ung nbi.
NSO kasi Birthcertifiaate ko and para maka kuha NBI clearance need ko ng PSA birthcertificate. tpos need daw ID number saw ebsite kasi pipili ka ng ID type tpos lalagay mo ID number kaso kapag Pinili ko birthcertificate nanghihingi parin ID number eh diko alam kung saan yun help naman mga sir
NBI clearance 2021😁
Wala na pong renewal Ng NBI clearance kea Kung mapapansin ninyo walang slot na available o puno na kadalsan via online appointment.
Ang gawin ninyo Po gawa ka kayo Ng bagong account sa NBI at makikita nyu mgkaka slot na via online appointment😁
pwede po bang makuha agad ang nirenew na nbi sgurado kasi may hit ako, matatagalan pa bago makuha. pwede kaya bayaran yun para makuha agad? ty po response
So iba ang Christian sa Roman Catholic, sa Evangelical, sa Baptist, sa Church of Christ, sa Jesus Miracle Crusade? Wow.
Anyway, suggest ko guys kuha kayo clearance through online. Para pagdating mo sa nbi sa sinet mong appointment is databasing at releasing na lang kayo. If things go...
Hi.. Sino po dito ang nagregister online sa nbi? can you share the steps?... the complete detailed application form together with the reference # and barcode is not visible after the online registration....... help please.
sinu na po nakasubok sa nbi online application?kasi sa account po is may picture po duon kaso blank siya,required po ba yun na lagyan ng picture yun?nag aalangan kasi akung mag pay eh baka masayang if walang picture ung account ko sa nbi online,sorry sa off topic
mga boss help naman po.. nawala kasi lahat ng id ko..dahil sa bagyo pati birth certicate ko nasama.. ask ko lang pwede ba barangay id sa pagkuha ng nbi online???
good day,ask ko lang sa mga bagong nakakuha ng NBI clearance..hindi na ba pwedeng sa mismong nbi branch magbayad?tsaka 140 na ba talaga?...parang sobra naman pagtaas...
last year kasi(2016) kumuha ako 115 pa din tsaka pwede mismo sa nbi branch magbayad..
thanks!