DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. In human cells, both normal metabolic activities and environmental factors such as radiation can cause DNA damage, resulting in tens of thousands of individual molecular lesions per cell per day. Many of these lesions cause structural damage to the DNA molecule and can alter or eliminate the cell's ability to transcribe the gene that the affected DNA encodes. Other lesions induce potentially harmful mutations in the cell's genome, which affect the survival of its daughter cells after it undergoes mitosis. As a consequence, the DNA repair process is constantly active as it responds to damage in the DNA structure. When normal repair processes fail, and when cellular apoptosis does not occur, irreparable DNA damage may occur, including double-strand breaks and DNA crosslinkages (interstrand crosslinks or ICLs). This can eventually lead to malignant tumors, or cancer as per the two hit hypothesis.
The rate of DNA repair is dependent on many factors, including the cell type, the age of the cell, and the extracellular environment. A cell that has accumulated a large amount of DNA damage, or one that no longer effectively repairs damage incurred to its DNA, can enter one of three possible states:
an irreversible state of dormancy, known as senescence
cell suicide, also known as apoptosis or programmed cell death
unregulated cell division, which can lead to the formation of a tumor that is cancerousThe DNA repair ability of a cell is vital to the integrity of its genome and thus to the normal functionality of that organism. Many genes that were initially shown to influence life span have turned out to be involved in DNA damage repair and protection.
The 2015 Nobel Prize in Chemistry was awarded to Tomas Lindahl, Paul Modrich, and Aziz Sancar for their work on the molecular mechanisms of DNA repair processes.
Sir pahelp naman pagkatapos di madetect nung dati kong drive.yung isa na naman hindi madetect bakit kaya .ang last na nangyare po nagsleep tapos nirestart ko po.
Pa help po kung sino po ba nakakaranas ng gaya ng phone ko na parati nag restart ayaw mag off. Tsaka pag lowbat vibrate ng vibrate. Now lang po nangyari. Di nmn sira ang screen.
Hello everyone paki help naman po sa problema ko!!.. PLease ayaw kasi gumana ng Home button, recent apps at notication ng cp ko..ULTRA 1 ILLY PH ang Brand niya...Sana may sumagot..Thanks
comment nyo problem nyo try ko isolve.
-láρág nyo brand at model ng phone nyo.
-problema ng phone nyo.
solve ko nang walang kahirap-hirap.
-if ever ang problem ng android phone nyo is software corruption or malfunction which needs FLASHING or REPROGRAM. comment lang kayo kung gusto nyobisolve...
Pag minsan po hindi nadedetect yung hard disk drive ko kaya ginagawa ko inaayos ko ung sata cable at yung sa power tapos nadedetect kaso eto parin nalabas palit kaya ako os kasi ngpapabackup sya baka navirus kasi binoot time acan ko to kagabe dami virus sana merong makatulong sana ok pa hdd...