A transcriptional ac†ïvâ†ør is a protein (transcription factor) that increases transcription of a gene or set of genes. Ac†ïvâ†ørs are considered to have positive control over gene expression, as they function to promote gene transcription and, in some cases, are required for the transcription of genes to occur. Most ac†ïvâ†ørs are DNA-binding proteins that bind to enhancers or promoter-proximal elements. The DNA site bound by the ac†ïvâ†ør is referred to as an "ac†ïvâ†ør-binding site". The part of the ac†ïvâ†ør that makes protein–protein interactions with the general transcription machinery is referred to as an "activating region" or "activation domain".Most ac†ïvâ†ørs function by binding sequence-specifically to a regulatory DNA site located near a promoter and making protein–protein interactions with the general transcription machinery (RNA polymerase and general transcription factors), thereby facilitating the binding of the general transcription machinery to the promoter. Other ac†ïvâ†ørs help promote gene transcription by triggering RNA polymerase to release from the promoter and proceed along the DNA. At times, RNA polymerase can pause shortly after leaving the promoter; ac†ïvâ†ørs also function to allow these “stalled” RNA polymerases to continue transcription.The activity of ac†ïvâ†ørs can be regulated. Some ac†ïvâ†ørs have an allosteric site and can only function when a certain molecule binds to this site, essentially turning the ac†ïvâ†ør on. Post-translational modifications to ac†ïvâ†ørs can also regulate activity, increasing or decreasing activity depending on the type of modification and ac†ïvâ†ør being modified.In some cells, usually eukaryotes, multiple ac†ïvâ†ørs can bind to the binding-site; these ac†ïvâ†ørs tend to bind cooperatively and interact synergistically.

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  1. T

    Help Ms365 key or ac†ïvâ†ør

    Baka po meron kaya ac†ïvâ†ør or key para sa ms365 hindi na po kasi nagana yung dinownload ko dati na ac†ïvâ†ør. Salamat po. Godbless
  2. P

    Help Microsoft Office Professional Plus 2013 (Ac†ïvâ†ør)

    Mga paps may product key or ac†ïvâ†ør ba kayo for this version po. Pahingi po. Thank you
  3. J

    Help Pa share po ng windows 10 ac†ïvâ†ør mga ka phc

    ayaw gumana ng ac†ïvâ†ør na download ko pa share naman baka may ac†ïvâ†ør kayo andami ko na na try ayaw parin ma activate pero yung una na na iformat ko na windows 10 na activate naman yung pangalawa na na inupgrade ko lang sa windows 7 to windows 10 ayaw thanks in advance
  4. B

    Help Help Microsoft Office 2010 ac†ïvâ†ør

    mga boss baka meron po kayo jan, ac†ïvâ†ør ng microsoft office 2010 o yung ***** nya, o suggest na lang po kayo ng ibang version ng microsoft office na hindi na eexpire ang registration tia
  5. J

    Help Usb bootable Windows 10 Pro 64bit with Ac†ïvâ†ør with Microsoft 2021 with ac†ïvâ†ør

    Hello Good Morning baka po meron po kayong files ng Windows 10 Pro with Ac†ïvâ†ør patulong naman po magrereformat po kasi ako ng laptop ko,sa may mga mabubuting loob po jan..🙏🙏🙏
  6. S

    Russkov Ac†ïvâ†ør Power Ramdisk Windows stable 100% freee

    Supported iPhone / iPad models: Bypass passcode/hello link Hidden content Use it when you know it.
  7. K

    Help Adobe Ac†ïvâ†e?

    Sino po merong ac†ïvâ†ør ng Adobe products? Penge po ☺️ TiA!
  8. S

    Help Ms office 365 activate

    hi, may product key po ba kayo or ac†ïvâ†ør sa ms office 365 po ?
  9. P

    PC App Safe po ba ang kms ac†ïvâ†ør sa cmd?

    so gumamit po ako kms sa windows at Microsoft office sobrang dali po nung activation pero di ako sure kung okay lang yun or nasa risk na ung Computer ko pa help po
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    Magandang Araw mga ka PHC. May konting tanong lang ako sa mga expert na tech or kung sino nakakaalam. itatanong ko lang sana itong MASSGRAVE Ac†ïvâ†ør maituturing ba natin itong CRÃCKËD or GENUINE? Salamat po 😘💪
  11. E

    Help po need windows 10 ac†ïvâ†ør

    baka po may windows 10 pro ac†ïvâ†ør kayo, pwedeng maka hingi salamat
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    Help Is making windows acïvâør tool is îllégâl?

    Hello mga ka phc tanong kolang sa mga expert dyan if îllégâl ba gumawa ng tool for windows activation ? may irerelease sana ako ea hihi
  13. R

    Help Windows 10 Pro Ac†ïvâ†ør

    Hello po, meron po bang working na ac†ïvâ†ør for win 10 pro? Edition Windows 10 Pro Version 21H2 Installed on ‎05/‎11/‎2022 OS build 19044.1288
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    Help Microsoft Office 2021 Ac†ïvâ†ør

    mga paps question lng bakit ganito lumalabas? ni run as admin ko naman siya pero ganyan parin hindi ko tuloy ma activite office 2021 ko, help please
  15. S


    Windows 11 Professional Key A269N-WFGWX-YVC9B-4J6C9-T83GX Windows 11 Pro key ZK7JG-NPHTM-C97JM-9MPGT-3V66T Windows 11 Professional N Key MH37W-N47XK-V7XM9-C7227-GCQG9 Windows 11 Enterprise Key BPPR9-FWDCX-D2C8J-H872K-2YT43 Windows 11 Enterprise N Key RPH2V-TTNVB-4X9Q3-TJR4H-KHJW4 Windows 11...
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    Tutorial Windows All (7, 8, 8.1, 10) License Acïvâør FREE

    Windows 7, 8, 8.1, 10 Automatic Ac†ïvâ†ør FREE - @YOWZED #Supported products: - Windows 7 Professional - Windows 7 Professional N - Windows 7 Professional E - Windows 7 Enterprise - Windows 7 Enterprise N - Windows 7 Enterprise E - Windows 8 Core - Windows 8 Core Single Language - Windows 8...
  17. R

    CloudMoe Windows 10+/11 Activ@tion Toolkit

    Support for Windows 10 and Windows 11 (x86/x64/ARM64) The first release was built in January 2017. New version was open source now! Version (2.6.2 Build 220911-3) I'm looking for any activ@tor that allows Phoenix LiteOS activate since they didn't include pre-activated on their OS...
  18. 0

    Tutorial How To Activate Windows 7/8/8.1/10 & 11 using .bat File

    Hidden content STEPS: First Open Notepad and Copy the code above. Save the file to .bat extension on desktop. Right Click On The File and select "Run As Administrator" If Your Version is Supported Then your Windows will be Activated.
  19. K

    Help KMS Ac†ïvâ†ør LEGIT AND SAFE?

    Tanong ko lang sana kung legit ba si KMS Ac†ïvâ†ør, di ko kase alam kung may palaman ba o baka may mang backdoor once na ma activate itong windows ko. Di ko kase alam pano mag activate ng windows 10 in free lang sana. Saka na ako bibili ng genuine na license kapag may ipon na ako.
  20. E

    Windows 7, 8, 10 Direct ISO Download

    32 Bit Windows 7 Ultimate SP1 Windows 8 Pro Build 9600 Windows 10 Pro Build 2009 v2 64 Bit Windows 7 Ultimate SP1 Windows 8 Pro Build 9600 Windows 10 Pro Build 2009 v2 Cr4ck for Windows 7 - Windows Loader Windows 8 - KMSPico Windows 10 - Here If you have question, feel free to comment down...
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    Direct Link Windows 10/8/7 and Microsoft Office Ac†ïvâ†ør

    Windows 10/8/7 and Office Ac†ïvâ†ør Credits: R@in Password: windows
  22. P

    Closed Microsoft Office 2019 For Free Pasok!!

    Hello mga papsie.. Medyo matagal ako di naka post ah.. Hehe pero heto naman kapalit.. yung may mga act.iva.tor na jan sa MS Office 2019 dagdag nyo pato.. Supported Products Ms Office Standard 2019 Ms Office Professional Plus 2019 Procedure : Restart your PC Deactivate all Anti Virus Run...
  23. E

    Closed Windows 10 prO

    windows 10 pro ac†ïvâ†ør.. Wlang idodownload na app na puro virus lang ang laman.. Pm lng sa may kailangan mahirap na baka makatay pa. Legit to. Edit lang Trust lng ang kailangan.. Reply ko tut.. Like and pasasalamat lang okay na.. DL tas Open then Save as... Palitan mu yung file name bago mu...
  24. L

    Closed Activate windows 10

    Noob question lang po... Mawawala po ba lahat ng files ko pakag e activate ko yung Windows 10 gamit ang reloader? Nasa step 1 kasi na uninstall previous version with IObit Installer kaya yun di ko muna tinuloy baka mawala lahat ng file... TIA po sa sasagot...
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    Closed [help] ac†ïvâ†ør

    Mga master pahelp naman po, nagexpired na kasi yung Office 365 ko. I tried KMS but hindi gumana laging failed. Pano kaya gagawin ko dito napansin ko din dito sa office 365 ko is Home ρrémíùm sya and retail lang.
  26. N

    Closed Dulci ac†ïvâ†ør (please visit my thread)

    Guys! Kahit Dulci Ac†ïvâ†ør lang birthday gift nyo saken >.< . Napakalaking tulong po yun pag binigay niyo please :(
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    Tutorial Windows 10 permanent a c t i v a t o r ultimate 2.3.. updated links 11/9

    Windows 10 Permanent Ac†ïvâ†ør ultimate is a program that finder for mak and retail key in different servers for Windows 10 all types of publications. The Keys are automatically updated daily. This software is one of the best for Windows 10 Ac†ïvâ†ørs with daily mak and retail key updates. Its a...
  28. R

    Closed Looking for a windows 7 ac†ïvâ†ør

    Mga paps meron po ba kayo? yung wala naman po sanang palaman na malware. panay may malware po kasi yung nandito eh. salamat po
  29. B

    Windows 7 ac†ïvâ†ør

    disable antivirus first
  30. J

    Ac†ïvâ†ør for windows and office? pasok!

    I'm only sharing this software kasi gumana siya sa MS 2013 ko. This software is NOT MINE. I will only post the link if I got 10 requestors. Please allow me to do so. Good day!
  31. L

    Closed Sino may ms toolkit 2.6

    Windows Ac†ïvâ†ør ?
  32. S

    Closed Eset product ac†ïvâ†ør 6.5†ïvâ†ør_65.html 1.Boot in Safe Mode 2.Open mo yung nasa attachment. password: retzel29 3.Click Activate
  33. P

    Closed ac†ïvâ†ør all in one

    Can activate windows 8,8.1,10,office 2016.Please delete if repost.
  34. I

    Closed Windows 8 loader

    mga boss penge po ac†ïvâ†ør sa windows 8. :)